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Search Results for " antiplatelet aggregation "

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阻害剤

天然化合物

カタログ番号	製品名	別名	ターゲット
T5036	Cangrelor tetrasodium		GPR , P2Y Receptor
	Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects.		GPR , P2Y Receptor
T3536	AZD1283		P2Y Receptor
	AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithromboti...		P2Y Receptor
T6236	Ozagrel	OKY-046,Domenan	Thrombin , Prostaglandin Receptor
	Ozagrel (Domenan) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral isch...		Thrombin , Prostaglandin Receptor
T0230	Prasugrel	LY640315,CS-747,PCR 4099	P2Y Receptor
	Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those...		P2Y Receptor
T6625	Ozagrel hydrochloride	Ozagrel HCl,OKY-046 HCl	Thrombin , Prostaglandin Receptor
	Ozagrel hydrochloride (OKY-046 HCl) is a selective thromboxane A(2) synthetase inhibitor used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.		Thrombin , Prostaglandin Receptor
T0182L	Clopidogrel hydrogen sulfate	(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel	P450 , P2Y Receptor
	Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and aggregation.		P450 , P2Y Receptor
T6952	Prasugrel Hydrochloride	LY 640315,PCR 4099 (hydrochloride),Effient Hydrochloride,LY 640315 Hydrochloride,Prasugrel HCl	P2Y Receptor
	Prasugrel Hydrochloride (LY 640315 Hydrochloride) is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome.		P2Y Receptor
T24733	Roxifiban acetate	MK 0853,DMP754,DMP 755,DMP 754 acetate,DMP 754,DMP-754 acetate,DMP754 acetate,DMP-754	Integrin
	Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used in the study of human thrombocytopenia.		Integrin
T11825	LCB-2853		PPAR
			PPAR
T17039	Terbogrel	BIBV 308SE	Prostaglandin Receptor
			Prostaglandin Receptor
T26071	Rhamnetin tetraacetate
	Rhamnetin tetraacetate is a potent antiplatelet compound that strongly inhibits platelet aggregation induced by arachidonic acid, collagen and PAF.
T17200	UDM-001651		Others
	UDM-001651 is an effective and orally bioavailable protease-activated receptor 4 antagonists (IC50=4 nM; Kd=1.4 nM). UDM-001651 displays antiplatelet potency (IC50=25 nM) in a γ-thrombin-induced platelet-rich plasma aggr...		Others
T36726	6-keto Prostaglandin E1	6-keto Prostaglandin E1
	6-keto Prostaglandin E1 is a bioactive derivative of PGE1 that plays a role in antiplatelet aggregation and depolymerization.
T28044	MIPS-9922
	MIPS-9922 is a potent and selective PI3Kβ inhibitor with antiplatelet activity. MIPS-9922 inhibited integrin αIIbβ3 activation and αIIbβ3 dependent platelet adhesion to immobilized vWF under high shear. MIPS-9922 also p...
T5501	Clopidogrel thiolactone	2-oxoclopidogrel	P2Y Receptor
	Clopidogrel thiolactone (2-oxoclopidogrel) is a potent P2Y12 receptor inhibitor and a potent antiplatelet aggregation compound.Clopidogrel thiolactone is the active metabolic intermediate resulting from the first oxidati...		P2Y Receptor
T12596	(4E)-SUN9221		5-HT Receptor , Adrenergic Receptor
			5-HT Receptor , Adrenergic Receptor
T17231	Vicagrel		Others
	Vicagrel is an effective, orally active antiplatelet compound that enhances the inhibitory effect of aspirin on platelet aggregation and thrombosis in rodents by irreversibly inhibiting P2Y12 receptors and reducing metab...		Others

Compounds

cangrelor tetrasodium

T5036

Synonym:

Target: GPR, P2Y Receptor

Synonym: OKY-046,Domenan

Target: Thrombin, Prostaglandin Receptor

Prasugrel

T0230

Synonym: LY640315,CS-747,PCR 4099

Target: P2Y Receptor

Ozagrel hydrochloride

T6625

Synonym: Ozagrel HCl,OKY-046 HCl

Target: Thrombin, Prostaglandin Receptor

Clopidogrel hydrogen sulfate

T0182L

Synonym: (S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel

Target: P450, P2Y Receptor

Prasugrel Hydrochloride

T6952

Synonym: LY 640315,PCR 4099 (hydrochloride),Effient Hydrochloride,LY 640315 Hydrochloride,Prasugrel HCl

Target: P2Y Receptor

Roxifiban acetate

T24733

Synonym: MK 0853,DMP754,DMP 755,DMP 754 acetate,DMP 754,DMP-754 acetate,DMP754 acetate,DMP-754

Target: Prostaglandin Receptor

Rhamnetin tetraacetate

6-keto Prostaglandin E1

T36726

Synonym: 6-keto Prostaglandin E1

Clopidogrel thiolactone

T5501

Synonym: 2-oxoclopidogrel

Target: 5-HT Receptor, Adrenergic Receptor

カタログ番号	製品名	別名	ターゲット
T2S2109	Skimmianine	beta-Fagarine,Skimmianin,Chloroxylonine,Skimmiamine	Others
	1. Skimmianine (Chloroxylonine) is a spasmolytic agent. 2. Skimmianine (Chloroxylonine) shows pharmacol. props. similar to 2-(Methylamino)-1-phenyl-1-propanol BCJ45-G.		Others
T2230	Paeoniflorin	Peoniflorin	HSP , COX
	Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.		HSP , COX
TN1626	Eugenin		Others
	Eugenin is a chromone isolated from Peucedanum japonicum.Eugenin potent antiplatelet aggregation activity		Others
TN2086	Piperlotine A		Antibacterial
	Piperlotine A is an alkaloid that can be extracted from Piperonyssinus rolfsii and has antiplatelet aggregation activity.Piperlotine A showed inhibition of Mycobacterium tuberculosis in an in vitro assay with a MIC value...		Antibacterial
TN2027	Oxysanguinarine	8-Oxosanguinarine,Hydroxysanguinarine	Parasite
	Oxysanguinarine (Hydroxysanguinarine) possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus.		Parasite
T5725	Salvianolic acid B	lithospermic acid B,Dan Shen Suan B	Sirtuin , Autophagy
	Salvianolic acid B is a water-soluble antioxidant from Salvia extract. Salvianolic acid B plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant, and antithrombotic effect.		Sirtuin , Autophagy
T2727	Salvianolic acid B		Others
	Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant, and antithrombotic effect		Others
TN1254	3'-Methoxydaidzein		Sodium Channel
	3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively. 3'-Methoxydaidzein was specific for colla...		Sodium Channel
T5S2358	Dehydrocorydaline	Dehydrocorydalin,13-Methylpalmatine	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz...		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
TN4796	Piperlotine D		PAFR
	Piperlotine D shows potent antiplatelet aggregation activity.		PAFR
TN2087	Piperlotine C		PAFR
	Piperlotine C shows potent antiplatelet aggregation activity.		PAFR
T40595	Rubiayannone A
	Rubiayannone A is an anthraquinone glycoside with an antiplatelet aggregation activity.
TN1954	Moscatin		Others
	Moscatin exhibits antiplatelet aggregation activity.		Others
TN4922	Rubiarbonol B		Others
	Rubiarbonol B may have antiplatelet aggregation activities.		Others
TN1044	Quercetin 3-O-neohesperidoside		Others
	Quercetin 3-O-neohesperidoside shows anti-atherosclerosis, and antiplatelet aggregation activities.		Others
TMA0593	Broussoflavonol F		Tyrosinase
	Broussoflavonol F has antiplatelet effect, is partially due to an inhibitory effect on cyclooxygenase, can inhibit arachidonic acid (AA)-induced platelet aggregation. Broussoflavonol F shows inhibitory activities on mush...		Tyrosinase
T79948	Kadsurenin B
	Kadsurenin B, a platelet-activating factor (PAF) antagonist, exhibits neuroprotective properties and has a broad spectrum of pharmacological research applications, including antibacterial, anti-inflammatory, neuroprotect...
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs =...